The role of non-histone proteins in chromosome structure and function during mitosis

William began his PRF in Edinburgh in 1996. His studies focus on the packaging and segregation of chromosomes during cell division. Achievements during his PRF include identification of the chromosomal passenger complex, construction of the first human synthetic artificial chromosome and its use to study the epigenetic regulation of kinetochore assembly, proteomics/systems analysis of the mitotic chromosome proteome, and advances in understanding the role of non-histone proteins in mitotic chromosome structure and function.