The role of non-histone proteins in chromosome structure and function during mitosis
Year of award: 2015
Grantholders
Prof William Earnshaw
University of Edinburgh
Project summary
William began his PRF in Edinburgh in 1996. His studies focus on the packaging and segregation of chromosomes during cell division. Achievements during his PRF include identification of the chromosomal passenger complex, construction of the first human synthetic artificial chromosome and its use to study the epigenetic regulation of kinetochore assembly, proteomics/systems analysis of the mitotic chromosome proteome, and advances in understanding the role of non-histone proteins in mitotic chromosome structure and function.