The functional architecture of cerebellar computation


  • Prof Michael Häusser

    University College London

Project summary

Michael’s work aims to identify the fundamental units of computation in a well-organised neural circuit in the mammalian brain, the cerebellar cortex. This requires identifying motifs of connectivity within the neural circuit that define their functional properties and provide computational building blocks that are engaged during sensation and generation of movement. To address these challenges, Michael’s lab is using in vivo and in vitro electrophysiological, imaging and anatomical techniques in combination with behavioural approaches. The findings provide crucial constraints for constructing models of cerebellar cortex and targets for manipulation that have potential translational relevance for the many movement disorders that have a cerebellar origin.