Unravelling genetic causes and risk factors for severe male infertility

We will study the biological process of sperm production in fertile and infertile men. We will look at the genomes of large groups of men with severe male infertility, aiming to identify mutations in the DNA that can explain their infertility. We will also study the genome of children born through the use of assisted reproductive technologies (ART) to determine whether these technologies carry any health risk to these children.

This research will inform us about the biology of normal and abnormal human sperm production, identify the genetic causes of male infertility and provide insight into any risks of ART. This is useful to provide infertile men with information about the cause of their disorder and will help us develop novel and safer ART.