Understanding the role and consequences of systemic monocyte conditioning during infection

Year of award: 2014


  • Dr John Grainger

    University of Manchester

Project summary

John is an immunologist interested in mechanisms regulating inflammatory cells, in particular monocytes. Based at the Manchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, his group uses disease models alongside patient samples to explore inflammatory cell education during infection. Recently John’s work has focused on understanding how signals from the gut and lung instruct developing monocytes in the bone marrow following pathogen challenge and the consequences of this ‘systemic’ training. By identifying novel factors involved in this dialogue John aims to identify targets to modulate aberrantly activated inflammatory cells in chronic diseases such as inflammatory bowel diseases (IBD) or allergies.