Understanding the role of altered-ubiquitin homeostasis in motor neurone diseases

Ewout will use his Fellowship to study the role of altered-ubiquitin homeostasis in motor neurone disease. He will combine a range of cellular and animal models to understand how changes in ubiquitin homeostasis lead to motor neurone degeneration, and whether this pathway can be targeted to treat motor neurone disease. Ewout will be working between the labs of Professor Tom Gillingwater at the University of Edinburgh and Professor Kevin Talbot at the University of Oxford.