The role of CD200R1 signalling in regulating skin inflammation

Amy is an immunologist studying inflammatory skin diseases such as psoriasis. Her research investigates mechanisms that prevent a healthy skin immune system from responding to harmless environmental substances. Her hypothesis is that a failure of such regulatory mechanisms underlies inflammatory skin diseases. CD200R1 is a regulatory protein on the surface of many types of immune cells. Amy's work has shown that this protein plays an important role in regulating immune responses in skin and her current research aims to understand how this regulation occurs, and whether manipulating this protein represents a beneficial therapeutic strategy for inflammatory skin disease.