The role of anaemia and fetal haemoglobin in sickle-cell disease: clinical epidemiology to establish the evidence base for interventional trials of blood transfusion and hydroxyurea


  • Prof Julie Makani

    Muhimbili University of Health and Allied Sciences

Project summary

Julie’s work is focused on sickle-cell disease (SCD) and is based at Muhimbili University of Health and Allied Sciences in a programme integrating healthcare, research and training. Her Fellowship is held at Muhimbili and the Nuffield Department of Clinical Medicine, University of Oxford. Julie is looking at anaemia in SCD, determining the epidemiology of disease, and establishing interventions including blood transfusion and hydroxyurea. She is exploring disease mechanisms and disease-modifying factors - both genetic and environmental - that influence SCD, with collaborations in Africa, USA and the UK (London School of Hygiene and Tropical Medicine, King’s College London and Wellcome Trust Sanger Institute).

This grant was awarded under the scheme's previous name of Intermediate Fellowships in Public Health and Tropical Medicine.