The physiological role of clathrin light-chain diversity in vertebrates

Clathrin-coated vesicles are responsible for cell-cell interactions in eukaryotic organisms by mediating membrane traffic pathways that control receptor expression and organelle formation. This process regulates cellular metabolism, cell growth, and immune and nerve cell function. Using cell biology, protein chemistry and mouse genetics, Professor Brodsky will investigate how the light-chain subunits of clathrin coat influence the physiological function of clathrin in vertebrates and how clathrin light-chain diversity enables tissue-specific clathrin functions.