The molecular mechanism of Wnt-mediated asymmetric stem cell division

Shukry is a stem cell biochemist with research interests in understanding the extrinsic and intrinsic cues that choreograph stem cell behaviour during homeostasis, injury, and tumorigenesis. Recently Shukry has demonstrated that a localised source of Wnt signals induces oriented asymmetric cell division (ACD) of embryonic stem cells. By applying principles from bioengineering, stem cell biology and advanced imaging techniques, Shukry aims to gain insight into the underlying molecular mechanism of ACD at the single-cell level, as well as in a tissue context. These studies will aid in our ability to utilise and target critical cells for regenerative medicine.