The impact of genetic heterogeneity on synthetic lethality in cancer

Colm will use his Fellowship to study synthetic lethality in cancer. His primary focus is on understanding how synthetic lethal interactions are affected by genetic differences within and between individuals, with a view to improving the identification of robust synthetic lethal treatments. He will commence the Fellowship with Professor Alan Ashworth at the Institute of Cancer Research, working on large-scale RNAi screens. Later, Colm will work with Professor Walter Kolch at University College Dublin, where he will carry out computational analyses and mathematical modelling of synthetic lethality.