The assembly mechanism of higher-order protein assemblies

Florian is currently working in Ruedi Abersold's laboratory at the ETH Zurich, where he is developing mass-spectrometry tools to solve protein-complex architecture and dynamics. In particular, he is focusing on the development of new X-linking strategies for probing subunit topology and interaction in protein complexes, and aims to complement them with ion-mobility mass spectrometry. Combining information on subunit topology and interaction from X-linking with ion-mobility data should not only generate more complete interaction maps of investigated complexes but also greatly enhance the interpretation of EM densities and other high-resolution structures. Florian will also undertake periods of research in Carol Robinson’s laboratory at the University of Oxford.