Structural insights into the mechanisms of protein transport across biological membranes

Sarah is a structural biologist who is interested in the structure and function of membrane-embedded protein transport machines. Previously, she determined the novel structure of the core component of the bacterial twin-arginine protein transport system, TatC. Sarah is currently interested in applying a host of structural techniques, including X-ray crystallography and biochemical techniques, to understand the mechanistic details of protein transport machines in both bacterial and mitochondrial membranes. This work will be conducted in the laboratories of Dr Edmund Kunji (MRC, Cambridge), Dr Susan Buchanan (NIH, Bethesda) and Professor Trevor Lithgow (Monash University, Melbourne).