Statin-triggered novel resolvins as innovative resolution-based therapeutics in arthritis

Jesmond's research efforts are focused on the structural elucidation of omega-3 fatty acid-derived bioactive mediators, assessing their cellular targets and the molecular mechanisms they activate in the resolution of inflammation. Of particular interest is a new family of mediators that he has identified and termed thirteen series resolvins. These mediators potently regulate the immune response limiting unwanted side effects. Jesmond's aim is to determine how the production of these protective molecules becomes dysregulated in chronic inflammatory diseases such as rheumatoid arthritis. Additionally, he aims to develop ways to replenish their endogenous levels as well as to use these molecules as biotemplates for the development of new therapeutics.