Roles of symmetric and asymmetric histone H3 lysine 27 trimethylation in gene repression and epigenetic inheritance

Philipp is a biochemist and cell biologist who is interested in understanding how post-translational modifications of histone proteins regulate gene expression. His research particularly focuses on the molecular mechanisms of the repressive histone mark H3 lysine 27 methylation. By combining biochemical and microscopy-based approaches, his lab aims to determine how this mark controls the expression of developmental genes in embryonic stem cells and to clarify whether this mark can serve as an epigenetic signal that can pass on information to daughter cells.