Regulatory signalling networks between stem and niche cells in lung regeneration

Year of award: 2015


  • Dr Joo-Hyeon Lee

    University of Cambridge

Project summary

Joo-Hyeon's research aims to understand the interplay between stem and niche cells for lineage specification of adult stem cells in normal and diseased lungs. Signalling between stem cells and stromal cells is essential for organogenesis and adult tissue maintenance, but is poorly understood in the context of lung repair and regeneration. She will focus on identifying the key stem-stromal cell interactions and regulatory networks that allow for proper lung cell differentiation and injury repair using in vivo genetic mouse models and an in vitro organoid co-culture system that she has developed. This work will shed light on the repair mechanisms responding to regional damages along the pulmonary axis.