Regulation of splenic B-cell responses by tissue resident macrophages

The spleen provides a critical immune defence against pathogens that have reached the blood recirculation. Dr Arnon will study how immune responses are organised within the spleen, focusing on the roles of tissue-resident macrophages in regulating B-cell migration and activation. This research will use a combination of approaches, including novel mouse models and advanced imaging techniques, to determine the functional specification of distinct macrophage populations, and to define their roles in regulating humoral immune responses. These studies will advance our understanding of immunity against blood-borne antigens and the way by which tissue macrophages have evolved to address the specific requirements of their niche.