Regulation of neutrophilic inflammation by the HIF-PHD pathway

Year of award: 2012


  • Prof Sarah Walmsley

    University of Sheffield

Project summary

Dr Walmsley is a respiratory physician with a research focus on how oxygen sensing and metabolic regulation influence phagocyte host defence. Through a better understanding of the mechanisms by which hypoxia regulates key neutrophil functions and survival responses, Dr Walmsley aims to validate the therapeutic potential of selective manipulation of these pathways in patients with chronic neutrophil-dominant inflammatory lung diseases such as COPD.