Regulation of B-cell activation and differentiation by AU-rich element RNA binding proteins

My work focuses on understanding how RNA binding proteins that interact with AU-rich elements in RNA regulate the activation of B cells and their participation in the germinal centre reaction.

By studying where in B lymphocytes the RNA binding proteins are located, their physical interactions with RNA and with other proteins, and how they are required for B lymphocyte function, understanding of the basic molecular biology of these cells will be gained.

This knowledge could promote approaches to altering B lymphocyte function in health and disease.