Receptor tyrosine phosphatases in physiology and disease

Year of award: 2015


  • Dr Hayley Sharpe

    University of Cambridge

Project summary

Hayley is a cell biologist based at the Cambridge Institute for Medical Research. Her aim is to investigate the function and regulation of the receptor family of tyrosine phosphatases (RPTPs). Dysregulation of protein tyrosine phosphorylation is linked to developmental abnormalities and diseases such as cancer. Her research will focus on revealing the role of plasma membrane RPTPs in sensing the extracellular environment to influence cell behaviour. She uses genetics, functional proteomics and cell-based assays to reveal substrates and signalling pathways controlled by RPTPs in physiology and disease.