Protein poly(ADP-ribosyl)ation in genome stability and human disease

Ivan is a biochemist at the Sir William Dunn School of Pathology, University of Oxford. His laboratory employs biochemistry, cell biology, X-ray crystallography and animal models to study cellular responses to DNA damage. Ivan is particularly interested in understanding the pathways and proteins regulated by ADP-ribosylation, a post-translational protein modification known to be involved in DNA repair, modulation of chromatin structure, mitosis, transcription and apoptosis.