Natural killer cell mediated recognition of HIV-1 and adaption to KIR and HLA


  • Dr Christina Thobakgale

    University of KwaZulu-Natal

Project summary

Christina is an immunologist whose research focuses on understanding cellular and viral factors that influence disease progression in HIV-infected individuals. Her current focus is on innate immune responses, particularly mechanisms of natural killer (NK) cell dysfunction during HIV infection and their impact on the ability of NK cells to control disease. Her Fellowship supports investigations of the consequences of NK cell mediated viral escape in the control of HIV infections. Identification of mechanisms that underlie NK cell mediated protection in HIV infection is important as they have the potential to demonstrate the rationale for harnessing NK cells for therapeutic interventions.

This grant was awarded under the scheme's previous name of Training Fellowships in Public Health and Tropical Medicine.