Multidisciplinary studies of protein folding, misfolding and assembly

Year of award: 2011


  • Prof Jane Clarke

    University of Cambridge

Project summary

Jane is a biophysical chemist who is interested in the fundamental link between protein sequence, structure, function and interactions. The evolved primary sequence of a protein does not simply encode its final structure, but also the pathway by which it folds, how it avoids misfolding and the functional dynamics. Currently Jane’s research team (of biochemists, chemists and physicists) are using a multidisciplinary approach, combining ensemble and single molecular kinetic and equilibrium methods, structural tools, protein engineering and computer simulations to investigate folding, misfolding and assembly of large multidomain proteins, which make up over 75% of human proteins.