Modulating cytokine expression by T cells to protect the mucosa from chronic viral infections

Year of award: 2012


  • Dr Ian Humphreys

    Cardiff University

Project summary

Ian studies immune responses to viruses. Effective antiviral immunity at mucosal surfaces is critical for the restriction of transmission, persistence, and pathogenesis of viral pathogens. His research seeks to identify immune pathways that protect mucosal tissue from infection, and to understand the role that cytokines play in regulating these responses. Using an integrated approach, involving both human clinical specimens and in vivo models of virus infection, he hopes to identify how to modulate cytokine production by T cells in order to improve antiviral protection of mucosal tissue.