Modelling barriers to drug delivery and response to therapy in solid tumours using non-invasive magnetic resonance imaging

Simon is developing techniques for quantifying the structure and function of tumours using magnetic resonance imaging (MRI). MRI can be sensitised to the motion of water, which allows the structure of tissue to be probed via the restriction of water diffusion. Similarly, convective flow is used to quantify fluid flow within blood vessels, alongside abnormal flow between tumour cells. By characterising fluid dynamics and tumour structure, the overall aim of his research is to quantify and predict barriers to successful drug delivery.