Metabolic control of T-cell receptor signalling

Alessio is a biochemist who studies mechanisms of immune cell dysfunction. During this fellowship, he will be dissecting a hitherto unknown immune-inhibitory complex, identifying strategies to restore adaptive immunity during ageing and in tumour disease. 

Sponsored by Professor Michael L Dustin (University of Oxford) and mentored by Professor Mala Maini (UCL), Alessio will be also working with Professor Michael Karin (University of California, San Diego), Professor Erika Pearce (Max Planck Institute of Immunobiology and Epigenetics) and Dr Enrico Lugli (Humanitas Clinical and Research Center, Milan). The overall aim is to define the interplay between senescence and metabolic signals in controlling T-cell function.