Mechanisms of R-loop formation in mammals: interplay with RNA polymerase II regulation and epigenetic modifications

Working between the labs of Professor Adrian Bird (University of Edinburgh) and Professor Ana Pombo (Berlin Institute for Medical Systems Biology), Konstantina plans to increase our understanding of the interconnection of R-loops and RNAi-mediated repressive chromatin marks. Her research aim is to study the interplay of R-loop formation with Pol II regulation and epigenetic modifications.