Mechanism and structural analysis of Rab GTPase control systems in normal cells and human disease states


  • Prof Francis Barr

    University of Oxford

Project summary

Professor Barr will be studying a family of proteins known as Rab GTPases that regulate many steps in membrane trafficking. Rab GTPases form part of an essential recognition system which gives unique identity to organelle and vesicle membrane surfaces, enabling vesicles to be specifically recognised during transport. Professor Barr will explore how Rab GTPases are involved in membrane trafficking pathways within human cells in both normal and disease states.