Kinetochore – microtubule interactions: steps towards bi-orientation

Human cells store their genetic information in 46 chromosomes. To maintain this vital genetic information, a complete set of chromosomes must be inherited precisely by each daughter cell after cell division. Errors in this process cause cell death and various human diseases, such as spontaneous miscarriage during pregnancy, genetic abnormalities and cancers. 

Our research goal is to understand the basic mechanisms that ensure accurate chromosome inheritance when cells divide. These mechanisms involve how chromosomes efficiently and correctly interact with a cellular apparatus called the mitotic spindle that subsequently moves chromosomes into the new daughter cells. We will use advanced methods in cell biology, biochemistry, molecular genetics and computer simulation to examine chromosome interactions with the mitotic spindle in fine detail. 

The results of our research should contribute to understanding how various human diseases involving errors in chromosome inheritance arise – and how they might be prevented.