Insulin resistance: lessons from extreme phenotypes

Professor O'Rahilly will use a unique resource established in Cambridge, the Severe Insulin Resistance Cohort, to further explore the genetic contribution in the development of severe insulin resistance. Using a candidate gene approach, along with exome sequencing and cellular investigations, applied to extreme and other phenotypes, the research aims to uncover unrecognised syndromes of insulin resistance and provide insight into mechanisms of disease that might be susceptible to specific therapeutic interventions.