Innate immune regulation of pathologic CD4+ T-cell responses in inflammatory disease

Year of award: 2014


  • Dr Matthew Hepworth

    University of Manchester

Project summary

Matt is an immunologist who aims to understand how inflammation and immunity are orchestrated at mucosal barrier sites such as the gastrointestinal tract and lung. At the University of Manchester his group uses disease models and patient-derived samples to determine how a rare population of immune cells, known as innate lymphoid cells, act to control the magnitude of inflammatory immune responses towards foreign organisms and allergens. A greater understanding of how innate immune pathways regulate inflammation at mucosal barrier sites will inform the development of novel therapeutics to treat chronic human diseases such as inflammatory bowel disease and asthma.