In vitro differentiation of human embryonic stem cells can produce tractable and physiologically credible surrogates for monocyte-derived macrophages for use in HIV studies


  • Dr Sally Anne Cowley

    University of Oxford

Project summary

Sally began her research career working on host-pathogen interactions in mycobacteria (PhD, Royal College of Surgeons, University of London, and later at the Armauer Hansen Research Institute, Ethiopia). Her postdoctoral work (New England Deaconess Hospital, Boston, and Institute of Cancer Research, London) centred around signal transduction pathways involved in differentiation. Following a career break to raise her children, Sally was awarded her Fellowship in 2007, enabling her to develop a programme of research into the differentiation of human pluripotent stem cells to macrophages and their applications for host-pathogen studies (especially HIV), at the Sir William Dunn School of Pathology, University of Oxford. She has established and now heads the James Martin Stem Cell Facility (affiliated to the Oxford Stem Cell Institute), for work with human induced pluripotent stem cells, with key roles within the Oxford Parkinson's Disease Centre and EU IMI StemBANCC.