How regulation of deubiquitination by danger signals modulates and orchestrates inflammasome activation

Year of award: 2014


  • Dr Gloria Lopez-Castejon

    University of Manchester

Project summary

Gloria is a molecular immunologist studying fundamental mechanisms of inflammation. Her group is based at the Manchester Collaborative Centre for Inflammation Research and she is interested in the regulation of the inflammasome, a molecular complex required for the release of potent pro-inflammatory mediators, such as interleukin-1β. Her research investigates the relationship between danger signals, deubiquitinases (DUBs) and inflammasome activation in macrophages to establish novel roles for DUBs in the inflammatory process and, consequently, in inflammatory pathologies.