How chemokine signalling and antigen recognition are integrated by T cells

During his fellowship, James will investigate the role of G-protein-coupled receptors in the immunological synapse between antigen-presenting cells and T cells undergoing activation, with a particular focus on the behaviour of chemokine receptors. He will approach this using a range of imaging and microfluidic techniques to examine how the spatial organisation of these receptors is integrated into the highly compartmentalised platform of the immunological synapse. James will be based primarily in the laboratory of Professor Michael Dustin (University of Oxford), and will undertake additional work with Professor Savas Tay (ETH Zurich) and in collaboration with Professor Jason Cyster (University of California, San Francisco).