HIV-1 transactivation complex: structure, dynamics and druggability

Grantholders

  • Aditi Borkar

    University of Cambridge

Project summary

Aditi will be taking up the long-standing challenge of determining the structure and dynamics of the HIV-1 transactivation complex (TAC) to explore its druggability. She will commence her Fellowship by undertaking biophysical analyses of TAC with Dr Matthias Geyer (Universit├Ąt Bonn) and performing X-ray crystallography studies with Professor Thomas Steitz (Yale University) to understand the mechanism of transactivation. She will then simulate TAC dynamics with Professor Christopher Dobson (University of Cambridge) to identify putative drug targets therein. Aditi will also maintain close ties with her mentor, Professor Michele Vendruscolo at the University of Cambridge.