High-resolution genome-wide analysis of small-RNA-mediated translational regulation

Betty is currently based in Professor David Baulcombe's laboratory at the University of Cambridge, where she is investigating small-RNA-silencing pathways in both plant and animal systems, in order to gain new insights into the fundamental mechanisms of small-RNA-mediated translational control. Betty will use high-throughput deep-sequencing methods, such as ribosomal profiling and HITS-CLIP, to obtain ultra-high-resolution genome-wide data in multiple organisms. During the Fellowship, Betty will also collaborate with Professor David Bartel in the Whitehead Institute (MIT). The information obtained will further our understanding of the evolution and function of RNA-based gene regulation.