Hedgehog signalling in T cell effector and memory function in vivo

Year of award: 2015


  • Dr Maike de la Roche

    University of Cambridge

Project summary

Maike is a vet and immunologist based at the Cancer Research UK Cambridge Institute. She is interested in CD8 T cells, which protect the body against infection with intracellular pathogens and tumours. Maike's research aims to elucidate the role of the developmental Hedgehog signalling pathway in CD8 T-cell effector and memory cell differentiation, maintenance and function during infection and tumorigenesis. Advances in this field will greatly benefit therapeutic approaches against infection as well as immunotherapy in cancer patients.