Female infertility: deciphering the mechanisms that perturb ERa signalling in the hypothalamus

Bryn is a molecular endocrinologist with training in nuclear hormone receptor signalling and the hypothalamic pathways that govern female reproductive function. Using model systems, he is investigating how the cellular receptor for oestrogen controls the timing and progression of the ovulatory cycle. He is also interested in understanding how this control is lost during nutritional challenges such as obesity and anorexia. Ultimately, Bryn aims to identify novel therapeutic targets for the treatment of metabolic sub-fertility in women.