Dissecting neuronal specificity in hereditary neuropathy

James will use his Fellowship to elucidate the disease mechanism underlying the peripheral nerve disorder Charcot-Marie-Tooth disease type 2D (CMT2D). He will begin his Fellowship with Professor Giampietro Schiavo at UCL, where he will learn how to image axonal transport in live cultures and animals. James will then move to the laboratory of Professor Kevin Talbot at the University of Oxford, where he will develop induced pluripotent stem cell models of CMT2D to better understand the cause of neuronal susceptibility observed in the disease.