Defining mechanisms for pancreatic beta-cell dysfunction in type 2 diabetes

Type 2 diabetes is a leading cause of illness and death across the world and current strategies for prevention and treatment are inadequate.

I will identify fundamental processes involved in the development of type 2 diabetes by using human genetics and the molecular characterisation of the pancreatic islet to generate novel insights into disease biology.

My findings will provide the basis for more effective preventive and therapeutic approaches that can reduce the burden of disease.