Co-ordination of chromosome unlinking and segregation

I investigate the molecular mechanisms that control the organisation and processing of bacterial chromosomes throughout the cell cycle. My team’s research makes use of quantitative live-cell single-molecule imaging that enables the visualisation of the assembly and action of molecular machines such as MukBEF, the bacterial structural maintenance of chromosomes complex.

Combining this high-resolution imaging with mechanistic in vitro and in vivo biochemistry will advance our understanding of how bacteria and eukaryotes organise, segregate and repair their chromosomes.