Complement receptor signalling in Th-1 immunity

Complement is critically important in human health and disease. Dr Kemper's research seeks to define the function of complement in the regulation of adaptive Th1-mediated inflammation and autoimmune diseases, such as rheumatoid arthritis and scleroderma. She will investigate how the autocrine-activated receptor-signalling network regulates Th1 immunity, how dysregulation of these pathways contributes to Th1-driven autoimmune diseases, and how druggable targets in these pathways can be exploited to have a therapeutic impact upon autoimmunity.