Complement receptor signalling in Th-1 immunity


  • Dr Claudia Kemper

    King's College London

Project summary

Complement is critically important in human health and disease. Dr Kemper's research seeks to define the function of complement in the regulation of adaptive Th1-mediated inflammation and autoimmune diseases, such as rheumatoid arthritis and scleroderma. She will investigate how the autocrine-activated receptor-signalling network regulates Th1 immunity, how dysregulation of these pathways contributes to Th1-driven autoimmune diseases, and how druggable targets in these pathways can be exploited to have a therapeutic impact upon autoimmunity.