Characterisation of anti-inflammatory virulence determinants; their role in Heliobacter pylori persistence and gastric cancer

Amanda will be working in collaboration between Associate Professor Richard Ferrero's laboratory at the Monash Institute for Medical Research, Melbourne, and Professor Ian Henderson's laboratory at the University of Birmingham. During her Fellowship, Amanda will investigate the mechanisms underpinning the ability of the bacterium Helicobacter pylori to infect and persist within the human stomach. She will aim to characterise novel bacterial proteins that have the capacity to manipulate host immune cells – an important bacterial strategy to aid their survival in the stomach and, ultimately, cause severe gastric disease.