An intravital imaging approach to elucidate novel mechanisms of organ fibrosis and repair

Organ fibrosis is a major global healthcare burden, playing a key pathophysiological role in many common diseases including cardiovascular disease, cancer, and chronic diseases of the liver, lung and kidney. However, there are currently no effective anti-fibrotic treatments. Dr Henderson is a hepatologist whose lab is interested in the cellular and molecular mechanisms that drive organ fibrogenesis, and also the pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. His current research focuses on the development of an intravital imaging approach to elucidate novel mechanisms of organ fibrosis and repair. By understanding more about how organs scar, heal and regenerate, Dr Henderson and his team hope to develop new treatments for patients with fibrotic diseases.