Climate and Mental Health Award: Uncovering mechanisms between heat and mental health

This award will fund projects to advance our understanding of the biological, psychological and/or social mechanisms through which heat affects anxiety, depression and psychosis in the most impacted groups globally. 

Successful applications will identify relevant climate-resilient and/or mental health interventions with a realistic potential for real-world application.

Overview 

Lead applicant career stage:
Administering organisation location:
Anywhere in the world (apart from mainland China)
Frequency:
One-off
Funding amount:

£1 - 3 million per project

Funding duration:

3 - 5 years

Coapplicants:
Accepted

Upcoming application stage

Calculating next key date…
Application process timeline

Getting support with your application

We offer disability-related support for applicants. Read the disability-related support guidance if you:

  • are disabled or have a long-term health condition and you need help applying for funding
  • need help completing your project, for example, costs for assistive technology

If you need help with anything else, please contact us.

Who can apply 

Your experience

You can apply to this call if you are a team of researchers:

  • from any discipline relevant to mental health science and climate science
  • from an eligible organisation
  • based anywhere in the world (apart from mainland China)

We encourage applications from:

  • researchers at any stage of their career, including early career researchers and/or those who are new to the fields of either mental health science or climate science
  • researchers from or based in low- and middle-income countries (LMICs)

 
Read about the different applicant roles at Wellcome.

If you’ve spent time away from research

Career breaks, parental leave, sick leave

You can apply for this award if you have spent time away from research (for example, for a career break, parental leave or long-term sick leave). We will take this into consideration during the review of your application.

Retirement

If you have retired, you must have a guarantee of space from your administering organisation and you must contact us before applying.

Working part-time

Lead and coapplicants can be part-time. There is no formal minimum, but part-time applicants should still be able to contribute at least 20% of their research time to the project and their part-time work should be compatible with delivering the project successfully.
 

Who can’t apply 

You cannot apply if you have already applied for, or hold, the maximum number of Wellcome awards for your career stage. Find out how many Wellcome awards you can apply for, or hold, at one time depending on your career stage.

You cannot apply to this award if you plan to transfer funds into mainland China.

Is your organisation right for this call? 

What your administering organisation must do

Your administering organisation must:

  • Be able to sign up to Wellcome’s grant conditions and grant funding policies.
  • Give you the space and resources you’ll need from the start date to the end date of the award.
  • If based in the UK, meet the responsibilities required by the Concordat to Support the Career Development of Researchers. If based outside the UK, at a minimum the organisation must follow the principles of the Concordat.
  • Give you and any staff employed on the grant 10 days a year (pro rata if part-time) to undertake training and continuing professional development (CPD) in line with the Concordat to Support the Career Development of Researchers.
  • Provide a system of onboarding, embedding and planning for you when you join the organisation and/or start the award.
  • Provide you with the status and benefits of other academic staff of similar seniority. 

Where your administering organisation is based

Your administering organisation can be based anywhere in the world apart from mainland China.

Your administering organisation can be a:

  • higher education institution
  • research institute
  • non-academic healthcare organisation
  • not-for-profit or non-governmental research organisation

One organisation can submit multiple different applications.

Commercial organisations are not eligible to apply as administering organisations for this call. This means that the lead applicant cannot be based at a commercial organisation. However, coapplicants and collaborators can be based at commercial organisations.

Collaboration agreements

If your application involves a collaboration or partnership between multiple organisations, the partners must enter into a suitable collaboration agreement, including provisions that cover:

  • confidentiality
  • publication rights
  • access to background intellectual property
  • ownership of foreground intellectual property
  • arrangements for the protection, management and exploitation of foreground intellectual property

The lead applicant’s administering organisation is required under our grant conditions to own all the foreground intellectual property arising from the project and to take the lead in any commercialisation activity. For guidance, applicants are advised to read Wellcome's intellectual property policy.

What is a research environment?

Wellcome believes that a diversity of people and expertise leads to richer understanding and more impactful discoveries. Excellent research happens in environments where people from all backgrounds are treated with respect, supported and enabled to thrive.

Our definition of a research environment is not restricted to the quality of the infrastructure, but also includes the culture and behaviours that create excellent research practice. This includes research that is inclusive in design and practice, ethical and engaged with relevant community stakeholders as well as open and transparent.

Read more about research environment and culture.

Is your research right for this call? 

What your research proposal must include

This call will fund research that advances our understanding of the mechanisms in which heat can affect anxiety, depression or psychosis. Mechanisms of interest can be at the biological, psychological and/or social level. Projects must focus on the populations most impacted by heat, mental health problems or the intersection of both. Projects supported by this award must also illustrate the translational implications of the research either now or in the future. 

Research proposals should cover these topics:

  • heat
  • communities most impacted
  • mental health conditions in scope
  • mechanisms of focus
  • causal insights
  • translational opportunities
  • collaboration between mental health scientists and climate scientists 
  • lived experience involvement

Heat 

Projects must focus on heat as a stressor of relevance to climate change. This may include:

  • extreme heat events
  • chronic exposure to unusually high temperatures
  • elevated indoor temperatures due to high external ambient temperatures
  • urban heat island effects 

Teams must clearly describe what type of heat they are examining and justify why and how they plan to measure it.  

Research must focus on ambient temperature and not on temperature generated mechanically (for example, by workers being exposed to a furnace) or by physical exertion (for example, athletes raising core body temperature by exercise). However, applicants may consider how these types of heat interact with elevated ambient temperature (for example, outdoor workers working in hot environments). The only exception to this are studies testing the mechanisms between heat and mental health in laboratory settings (either in humans or with animal models), where artificially generated heat would be allowed.  

We encourage applicants to consider potential environmental effect modifiers and/or confounding variables such as humidity, air pollution, access to air conditioning and other relevant variables, depending on the nature of the project.  

Work on exposure to cold temperatures is not eligible for this call.

Most impacted communities 

Projects must focus on communities most impacted as part of their study. 

By most impacted, we mean most affected by heat or by mental health problems and/or at the intersection of heat and mental health. 

Projects are expected to meaningfully engage relevant stakeholders and communities from the outset. This should be reflected in the composition of the team and the design of the research proposal. Wellcome supports the use of an engaged research approach, which asks researchers to include community engagement in the design of their project while being inclusive of a range of stakeholders. 

For this award, relevant stakeholders and communities could include:

  • local or national governments
  • civil society and community-based organisations
  • international or multilateral organisations
  • private sector partners

The only exception to this are studies focusing solely on animal models. These studies are eligible but we expect the authors to justify why their findings may be of relevance to most impacted communities.

Mental health conditions in scope

This funding call is focused on projects that investigate anxiety, depression and psychotic disorders.

This includes:

  • all types of anxiety and depressive disorders (including obsessive compulsive disorder and post-traumatic stress disorder)
  • all forms of psychotic disorders (including schizophrenia, postpartum psychosis and bipolar disorder)
  • transdiagnostic symptoms strongly associated with the above conditions (for example, threat hyperreactivity, repetitive negative thinking or suicidality)
  • physical health outcomes in populations living with anxiety, depression and/or psychotic disorders (for example, emergency hospital admissions, or mortality, including completed suicides)

We recognise that the current diagnostic categories are imperfect but removing all categories or creating new ones also presents difficulties. While we do not specify any particular diagnostic or classification system, we expect applicants to use a framework and measurement approach that fits the aim of their study and to provide a clear justification.

Projects can include populations living with other physical or mental health conditions as long as the focus remains on anxiety, depression and/or psychosis.

We recognise that climate anxiety (anxiety relating to climate and ecological crises) may be of interest for those studying the intersection between heat and mental health. We see the changing climate as an important issue that may contribute to or cause clinically significant anxiety. Projects may study climate anxiety in the context of anxiety that reaches the level of a mental health problem that impairs functioning. The link between anxiety related to thoughts or fears about climate change and heat would need to be made explicit for this call. 

Mechanisms of focus 

Applicants need to reference evidence for the association between heat and their mental health outcome of focus. 

Applicants also need to provide evidence to justify the choice of the mechanism(s) of focus. While we recognise the exploratory nature of this area, this justification must be based either on preliminary evidence (for example, pilot data) or on indirect evidence for the relationship both between heat and the mechanism(s) under investigation as well as between mental health and the mechanism(s) of focus.  

We encourage proposals conducting research on one mechanism at multiple levels of explanation (for example, molecular, cellular, systems, cognitive, behavioural, social, environmental or societal). Projects can also look at multiple mechanisms at the same time and at their interactions. 

Causal insights 

Projects should move beyond building correlational evidence on the relationship between heat and mental health. Projects funded by this call should lead to deeper understandings of the causal mechanisms behind this relationship. Understanding the mechanisms that connect heat and mental health will help us develop new and improved ways to predict, identify and intervene for mental health problems as early as possible. 

We are not setting specific methods that must be used. Some possible methods include:

  • experimental and quasi-experimental designs (for example, experimental medicine approaches or randomised controlled trials)
  • manipulation or use of experimental models (for example, iPSC-derived neurons, glia, organoids or animal models)
  • network models (for example, Bayesian networks)
  • causal mediation analysis and structural equation modelling based on longitudinal data
  • observational designs allowing causal inference (for example, Mendelian randomisation, difference in differences design or propensity score matching)
  • causal models (for example, causal pie model, Pear’s structural causal model or Rubin causal model)

Proposals need to justify the inclusion of any work packages that do not use causal methodologies. Qualitative research, observational longitudinal analysis and/or measurement development/validation is allowed for this call if it helps to address the overall research question(s).

Translational opportunities 

Proposals must consider and clearly describe the potential impact of the proposed project and how, if successful, it would contribute to translational work supporting real-world application (either directly or over time). Our recent report provides more information on the translation pipeline in mental health research. 

Translational opportunities may include:

  • considerations for improving mental health interventions (for example, psychotropic medications) in the context of heat
  • integration of mental health consideration in heat adaptation plans and the integration of heat considerations within mental health policies
  • better understanding of the development, maintenance, and resolution of anxiety, depression and psychosis under the stressor of heat with implications for possible new or improved early interventions

Collaboration between mental health scientists and climate scientists 

Projects must bring together climate scientists and mental health scientists as well as additional expertise as relevant, including but not limited to:

  • climate scientists
  • meteorologists/biometeorologists
  • psychiatrists, psychologists and social scientists
  • science, technology, engineering and mathematics
  • humanities (for example, historians and ethicists)
  • epidemiologists
  • lived experience experts
  • clinical and allied health sciences
  • experimental medicine
  • neuroscientists

Each project must have a minimum of one climate scientist and one mental health scientist as part of the core team (the lead applicant and coapplicants).

Lived experience involvement

Research proposals must involve lived experience expertise of anxiety, depression and/or psychosis unless there is a strong justification for not doing so.

We recognise that there is a range of ways that research teams can involve and collaborate with lived experience experts. This may include, but is not limited to:

  • expert advisors
  • coapplicants
  • collaborators
  • advisory group members

We are open to any methods of involvement that teams choose but lived experience experts must be involved in the most appropriate and ethical ways to inform multiple aspects and stages of the research project.

Lived experience experts should be engaged as colleagues who use their personal knowledge and expertise to inform the strategic direction, governance, design and delivery of the research.   

Projects with human participants must use, as a minimum, one or more of our recommended common measures in the collection of new data. You may also collect data using any other measure(s).  

This work must also comply with our policy on research involving human participants.

Kinds of research that are not right for this call  

Research that is not right for this call includes projects that:

  • focus on evaluating the efficacy or effectiveness of an intervention
  • focus mainly on environmental variables that are not heat (for example, cold temperatures or air pollution)
  • focus on other conditions besides anxiety, depression and psychosis (for example, projects where the primary focus is on neurodevelopmental conditions, neurodegenerative conditions and mental health conditions outside of the broad categories of anxiety, depression and/or psychosis)
  • propose methods that would only allow for correlation/associative insights into mechanisms rather than causal insights
  • focus on populations that are not most impacted in the context under investigation
  • are prevalence studies exploring different rates of mental health problems under different environmental conditions (for example, hot and cold climates) but do not test mechanisms
  • focus on a mechanism that has no direct or indirect evidence for its link to heat and mental health
  • do not have appropriate expertise from both mental health and climate sciences
  • do not comply with Wellcome’s research environment principles of open science and relevant diverse inputs 

Research costs we'll cover 

You can ask Wellcome to pay for:

How to apply 

Before you apply

Submit your application to your administering organisation for approval

  • Complete your application form on Wellcome Funding.
  • Submit it to the 'authorised approver' at your administering organisation for approval. Make sure you leave enough time for the approver to review and submit your application before the deadline. The approver may ask you to make changes to your application.

Administering organisation approves and submits it to Wellcome

  • Your application must be submitted by 17:00 (GMT) on the deadline day, 21 January 2025.  

Shortlisting

  • We will check your eligibility for the call and that your proposed research is within the call’s scope of funding. If your application is ineligible or is not within the funding scope, we will withdraw your application and contact you to explain why.
  • A committee will assess eligible and in-scope applications against the assessment criteria outlined on this page, to make shortlisting recommendations to Wellcome.
  • Committee membership will be comprised of a diverse range of international members and will take into account Wellcome’s diversity and inclusion priorities.
  • If your application is shortlisted, we will invite you for interview. We anticipate shortlisting decisions to be sent to applicants in March 2025. Interviews will be held virtually.

Written expert review

  • We will seek external written expert review on shortlisted applications. Reviewers will be selected based on their expertise within the relevant research field and not on their level of seniority.
  • Unattributed comments will be sent to shortlisted applicants before the interview. 

Interview

  • The committee will interview shortlisted applicants online and make funding recommendations to Wellcome. Interviews are scheduled to take place 28-30 May 2025.
  • The lead applicant will attend the interview, accompanied by up to three coapplicants.
  • Accessibility requirements will be accommodated.
  • You will be asked to give a presentation at the start of your interview. Details of the requirements for this presentation, and the date when slides need to be submitted to Wellcome, will be shared in advance.
  • We will provide further information on the structure of the interview and committee membership before the interview.
  • The focus of the interview will be on questions and answers. The committee will assess the application against the full set of assessment criteria, rather than one specific aspect of the proposal.
  • The committee will consider your application, the expert reviewers’ comments and interview responses when making funding recommendations to Wellcome. 

Funding decision

  • Final funding decisions will be made by Wellcome’s Mental Health and Climate and Health Teams.
  • You will receive an email notification of the funding decision soon after the decision has been made in June 2025.
  • The reasons for a decision will be provided to unsuccessful interviewed applicants in writing. 

Timing considerations for your application 

You must leave enough time for:

  • reading everything on this page before applying
  • you and your coapplicants to complete the application
  • your administering organisation to review and submit the application
  • the authorised organisational approver at your administering organisation to approve and submit your application to Wellcome by 17.00 GMT on the deadline day

Where to apply

Apply for this scheme on the Wellcome Funding platform. You can save your application and return to it at any time. 

Download the application questions.

Get some tips to help you write your grant application.

How applications are assessed 

For consistency, we will evaluate all applications using the same weighted assessment criteria. 

Essential criteria and weightings

There are four weighted assessment criteria for applications:

  1. research question(s), proposed methodology and translation (55%)

  2. suitability and expertise of the team (15%)

  3. lived experience involvement (15%)

  4. suitability of research location and approach to research environment (15%)   

Research question(s), proposed methodology and translation (55% weighting) 

Potential and impact  

  • The proposed research will lead to an increased understanding of the mechanisms underpinning the relationship between heat and anxiety, depression and/or psychosis. 

Rationale and strength of evidence

  • There is evidence that heat negatively impacts anxiety, depression and/or psychosis through the proposed mechanism.
  • There is a clear rationale for using the specific measure/conceptualization of heat proposed and this is relevant as a stressor in the context of climate change.
  • There is a clear rationale for why the community of study is considered to be most impacted in context.
  • The rationale for choosing a particular mental health outcome includes evidence that the outcome is considered relevant and important to people with lived experience who are most applicable to your research (a brief rationale is sufficient).

Proposed methodology

  • The research design clearly addresses the research question(s) and proposed hypothesis, seeking to gain causal insights on how heat affects the selected mental health outcomes.
  • The research design features methods that make causal inferences rather than infer associations between heat and mental health.
  • The project is well-designed and feasible using the resources and timelines proposed (for example, a recruitment plan is in place and is achievable and all components of the project have been appropriately costed).
  • The project includes work on most impacted populations. The study design should ensure the population is appropriately represented (for example, through sampling approaches, study site selection, inclusion/exclusion criteria or sub-group analyses).

Path to translation 

  • The project will contribute (directly or in the future) towards translational research resulting in either climate resilient solutions and/or mental health interventions. We have produced a report to help researchers in mental health consider the translational impact of their research from the earliest stages.
  • This could include, for example:
    • providing evidence that directly influences policy (for example, heat action plans)
    • public engagement activities to raise awareness of the links between heat and mental health and underlying mechanisms
    • a small pilot of an intervention that addresses the mechanism(s) under investigation (for example, a heat adaptation technique, a proof of concept for improved mental health interventions such as a psychotropic medication)
    • developing a screening tool to assess risk of heat induced mental health problems
    • development and validation of a new measure
  • The application identifies possible translational partners that could undertake this work.
  • The potential for scale-up across different settings and the potential impact of the translational implication should be taken into consideration.

Suitability and expertise of the team (15% weighting) 

The project features an integrated, collaborative plan of work that includes climate scientists, mental health scientists and individuals with lived experience. 

The lead applicant has (appropriate to their career stage):

  • research experience relevant to the project, as shown through research outputs and/or preliminary data
  • the experience needed to drive and lead a collaborative, large-scale research project and/or the necessary support structures in place to enable this
  • experience of people and research management

The coapplicant(s) has/have:  

  • the expertise, time and resources needed to deliver the project, with their contribution to the project being significant and justified 

The team:  

  • has the necessary expertise and technical skills, as well as the appropriate variety of disciplines and perspectives, to deliver the proposed project
  • includes lived experience experts and/or has the necessary skills to effectively involve and collaborate with people with lived experience of mental health problems in the different stages of the proposed research
  • has members who are all necessary to deliver the proposed research and there is proof of concept that the proposed collaboration will be feasible and effective (for example, the team has appropriate management plans in place describing how the collaboration will be equitably organised and managed day-to-day)
  • has contributed towards and is committed to fostering a positive and inclusive research environment, which demonstrates a commitment to equity, diversity and inclusion

Lived experience involvement (15% weighting)

  • People with lived experience are meaningfully involved at multiple stages, including the conception, planning, design, delivery and dissemination of the project. There is a clear rationale for their inclusion (or exclusion) at each stage. You can access guidance on embedding lived experience expertise in your research.
  • Lived experience perspectives are represented across the project, including in leadership and governance roles.
  • Lived experience experts have relevant experience and expertise applicable to the research, including being representative of the research location.
  • People with lived experience are compensated appropriately for their time.   

Suitability of research location and approach to research environment (15% weighting) 

Research location   

  • The administering organisation is supportive of the research project. For example, it aligns with the organisation’s strategy and it provides in-kind or financial support in the form of PhD students, administrative or technical support, and training opportunities.
  • The applicants have access to the necessary research infrastructure. 

Research environment 

  • The application provides a detailed description of how the team will foster a positive and inclusive research culture. This could include, but is not limited to, information about:
    • development
    • research practices
    • leadership
    • appropriate safeguarding measures for team members and collaborators, including people with lived experience
  • There is a clear plan on how to manage an integrated collaborative project. 

Ethical, open, equitable and engaged research conduct   

The application provides: 

  • An implementation plan with details about appropriate oversight, governance, monitoring, standard operating procedures and methods for course correction (as needed).
  • A detailed description of a suitable outputs management plan.
  • Information about how the research outputs will be made available to those who need them (for example, policymakers, communities and industry) and in which formats.
  • Details about the relevant ethical, social and cultural implications of the proposed work, and how the study team plans to manage these issues, both in the conduct and oversight of the study and in the communication of its findings.  

Key dates 

Application process timeline

You must submit your application by 17:00 GMT on the deadline day. We don’t accept late applications.

  1. Week commencing 30 September 2024

    Full details of the award are published and the call opens to applications

  2. 9 October 2024, 9:30 - 10:30 BST

    Funding webinar

    Watch the recording
  3. 31 October 2024

    Neuromatch deadline

    Register to find collaborators
  4. 18 December 2024

    Scope check deadline

  5. 21 January 2025

    Application deadline

  6. March 2025

    Shortlisting

  7. 28 - 30 May 2025

    Interviews

    Interviews will be held virtually.

  8. June 2025

    Funding decision

Downloads 

Contact us