Improving the treatment of malaria


  • Prof Nick White

    University of Oxford

Project summary

Nick’s PRF aims to improve the treatment of malaria and thereby contribute to malaria elimination. Building on extensive studies of antimalarial pharmacokinetics, pharmacokinetic-pharmacodynamic relationships will be characterised for efficacy and toxicity. This involves development of field-adapted assay methodologies, optimal design population pharmacokinetic studies, and clinical studies in severe and uncomplicated falciparum and vivax malaria. Dose modification in important sub-groups such as young children, pregnant women, and HIV and tuberculosis co-infected patients should improve therapeutic responses and reduce selective pressures to the emergence of resistance.