Unravelling the whipworm niche at the host intestinal epithelia

Whipworms are parasites that live inside the gut lining of 500 million people worldwide causing the disease Trichuriasis. Whipworms remain in their host for years by interacting with the gut lining and surrounding cells to manipulate gut structure and immune responses. How the parasite mediates these interactions is not understood. I aim to determine how whipworms invade, colonise and persist in the gut. Using a new model I developed based on ?mini-guts?, the first to mimic whipworm infections in a lab dish, together with microscopy and sequencing, I will characterise: 1) the molecular and cellular changes that happen in the whipworm and the gut lining and surrounding cells when the parasite enters and colonises the gut and; 2) the interactions that allow the parasite to persist and the gut lining to repair during chronic infections. This knowledge will open new avenues to eradicate whipworm infections and control gut inflammatory diseases.