Two-dimensional laser mass spectrometry: new proteomics for clinical biology of breast cancer and other diseases

Marina completed her PhD at Technion – Israel Institute of Technology in 2001 before moving in 2003 to the German Cancer Research Centre, DKFZ, Heidelberg, as a Minerva postdoctoral fellow, to work on development of mass spectrometry methods for protein phosphorylation analysis. In 2008, Marina was awarded a DFG-funded principal investigator fellowship, held at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. Early in 2010 she moved to London for family reasons and subsequently filled a few managerial and teaching lecturer positions. Marina is now delighted to return to active academic research at Imperial College London. During her Fellowship, Marina will be working on the development of a new general proteomic technology for structural analysis of proteins and their post-translational modifications using mass spectrometry and femtosecond laser pulses. This multidisciplinary approach will be applied to explore the role of protein post-translational modifications in the development of breast cancer resistance to endocrine therapy. In this research, she and her colleagues hope to identify improved therapeutic targets for breast cancer endocrine treatment.