Towards a molecular understanding of neurotransmitter transporter cellular activities

Year of award: 2013


  • Dr Simone Weyand

    University of Cambridge

Project summary

Simone is a biochemist and biophysicist who has worked on the structure determination of membrane proteins, such as the bacterial transporter Mhp1 and the human histamine H1 receptor, by the use of X-ray crystallography. Her Fellowship work uses a holistic approach to understanding the molecular mechanism of human neurotransmitter transporters by investigating the high-resolution structure and the functional analysis and trafficking in the cell. This combined approach, including different techniques, will provide deeper insights into the basic principle of action of these proteins and will eventually enable a more rational and efficient drug design.