The role of long non-coding RNAs in pluripotency and neuronal differentiation

Alex is investigating the mechanisms by which long non-coding RNAs contribute to early mammalian development, using the transition from embryonic stem cell to neural precursor cell as a paradigm. He will perform structural and mutational analyses in the laboratory of Professor Marc Bühler (Friedrich Miescher Institute, Basel), single-cell RNA sequencing analyses in collaboration with Professor Sarah Teichmann (EBI-Sanger, Hinxton), and single-molecule imaging approaches in collaboration with Professor Daniel Zenklusen (Université de Montréal).