The cellular and molecular mechanics of malaria parasite invasion of the human erythrocyte

Dr Baum's programme of research aims to address key questions in understanding how malaria parasites (Plasmodium species) invade the red blood cell – a critical step in the pathogenesis of malaria disease. The focus of the programme is aimed at every level of investigation, from atomic resolution of the parasite motor and single-molecule biophysical dissection of parasite motor force, to fixed and live imaging of parasite cells on the move. Dr Baum will be combining each of these approaches with comparative Plasmodium biology and, critically, inclusion of the host erythrocyte cell biology, towards the ultimate goal of understanding key events in parasite invasion and the identification of weaknesses that can be targeted to stop it.